3IT8

Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein

3IT8 の概要

• エントリーDOI: 10.2210/pdb3it8/pdb
• 分子名称: Tumor necrosis factor, 2L protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: mhc class i homolog, cell membrane, cytokine, disulfide bond, glycoprotein, lipoprotein, membrane, myristate, phosphoprotein, secreted, signal-anchor, transmembrane, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 335667.46

構造登録者

Yang, Z.,West Jr., A.P.,Bjorkman, P.J. (登録日: 2009-08-27, 公開日: 2009-10-20, 最終更新日: 2024-11-06)

主引用文献

Yang, Z.,West, A.P.,Bjorkman, P.J.
Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein
Nat.Struct.Mol.Biol., 16:1189-1191, 2009

PubMed Abstract: The poxvirus 2L protein binds tumor necrosis factor-alpha (TNFalpha) to inhibit host antiviral and immune responses. The 2.8-A 2L-TNFalpha structure reveals three symmetrically arranged 2L molecules per TNFalpha trimer. 2L resembles class I major histocompatibility complex (MHC) molecules but lacks a peptide-binding groove and beta2-microglobulin light chain. Overlap between the 2L and host TNF receptor-binding sites on TNFalpha rationalizes 2L inhibition of TNFalpha-TNF receptor interactions and prevention of TNFalpha-induced immune responses.

PubMed: 19838188
DOI: 10.1038/nsmb.1683

実験手法

X-RAY DIFFRACTION (2.8 Å)