3IRO

Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase complexed with NADPH and Q-8 antifolate

3IRO の概要

• エントリーDOI: 10.2210/pdb3iro/pdb
• 関連するPDBエントリー: 2H2Q 3CL9 3CLB 3HBB 3INV 3IRM 3IRN
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, 5-[3-(3-fluorophenoxy)propoxy]quinazoline-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: trypanosoma cruzi, dhfr-ts antifolate complex, methyltransferase, multifunctional enzyme, nadp, nucleotide biosynthesis, one-carbon metabolism, oxidoreductase, transferase
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 241162.04

構造登録者

Chitnumsub, P.,Yuvaniyama, J.,Yuthavong, Y. (登録日: 2009-08-24, 公開日: 2010-07-28, 最終更新日: 2023-09-06)

• 主引用文献: Chitnumsub, P.,Yuvaniyama, J.,Vilaivan, T.,Vanichtanankul, J.,Kamchonwongpaisan, S.,Yuthavong, Y.; Structural basis of antifolate inhibition of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase; To be Published,

実験手法

X-RAY DIFFRACTION (2.8 Å)