3IPY

X-Ray structure of Human Deoxycytidine Kinase in complex with an inhibitor

3IPY の概要

• エントリーDOI: 10.2210/pdb3ipy/pdb
• 関連するPDBエントリー: 3IPX
• 分子名称: Deoxycytidine kinase, D-MALATE, 4-(1-benzothiophen-2-yl)-6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidine, ... (4 entities in total)
• 機能のキーワード: human deoxycytidine kinase, atp-binding, kinase, nucleotide-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens
• 細胞内の位置: Nucleus: P27707
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59153.03

構造登録者

Tari, L.W.,Swanson, R.V.,Hunter, M.,Hoffman, I.,Stouch, T.R.,Carson, K.G. (登録日: 2009-08-18, 公開日: 2010-08-18, 最終更新日: 2023-09-06)

• 主引用文献: Jessop, T.C.,Tarver, J.E.,Carlsen, M.,Xu, A.,Healy, J.P.,Heim-Riether, A.,Fu, Q.,Taylor, J.A.,Augeri, D.J.,Shen, M.,Stouch, T.R.,Swanson, R.V.,Tari, L.W.,Hunter, M.,Hoffman, I.,Keyes, P.E.,Yu, X.C.,Miranda, M.,Liu, Q.,Swaffield, J.C.,David Kimball, S.,Nouraldeen, A.,Wilson, A.G.,Foushee, A.M.,Jhaver, K.,Finch, R.,Anderson, S.,Oravecz, T.,Carson, K.G.; Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.; Bioorg.Med.Chem.Lett., 19:6784-6787, 2009; PubMed: 19836232; DOI: 10.1016/j.bmcl.2009.09.081

実験手法

X-RAY DIFFRACTION (2.54 Å)