3IPH

Crystal structure of p38 in complex with a biphenylamide inhibitor

3IPH の概要

• エントリーDOI: 10.2210/pdb3iph/pdb
• 関連するPDBエントリー: 2ZAZ 2ZB0 2ZB1 3D7Z 3D83
• 分子名称: Mitogen-activated protein kinase 14, 6-[5-(cyclopropylcarbamoyl)-2-methylphenyl]-N-(cyclopropylmethyl)pyridine-3-carboxamide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: p38, serine/threonine protein kinase, map kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42373.25

構造登録者

Somers, D.O. (登録日: 2009-08-17, 公開日: 2009-11-24, 最終更新日: 2023-11-22)

• 主引用文献: Aston, N.M.,Bamborough, P.,Buckton, J.B.,Edwards, C.D.,Holmes, D.S.,Jones, K.L.,Patel, V.K.,Smee, P.A.,Somers, D.O.,Vitulli, G.,Walker, A.L.; p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression.; J.Med.Chem., 52:6257-6269, 2009; PubMed: 19772287; DOI: 10.1021/jm9004779

実験手法

X-RAY DIFFRACTION (2.1 Å)