3IOE

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.95 Ang resolution in complex with 5'-deoxy-5'-((R)-3,4-dihydroxybutylthio)-adenosine

3IOE の概要

• エントリーDOI: 10.2210/pdb3ioe/pdb
• 関連するPDBエントリー: 1N2H 3COV 3COW 3IOB 3IOC 3IOD
• 分子名称: Pantothenate synthetase, 5'-S-[(3R)-3,4-dihydroxybutyl]-5'-thioadenosine, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: mycobacterium tuberculosis, pantothenate biosynthesis, enzymes, ligase, inhibitors, drug design, fragment-based, dynamic combinatorial chemistry, atp-binding, magnesium, metal-binding, nucleotide-binding
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64353.63

構造登録者

Ciulli, A.,Scott, D.E.,Abell, C. (登録日: 2009-08-14, 公開日: 2009-12-01, 最終更新日: 2023-09-06)

• 主引用文献: Scott, D.E.,Dawes, G.J.,Ando, M.,Abell, C.,Ciulli, A.; A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry; Chembiochem, 10:2772-2779, 2009; PubMed: 19827080; DOI: 10.1002/cbic.200900537

実験手法

X-RAY DIFFRACTION (1.95 Å)