3IO9
BimL12Y in complex with Mcl-1
Summary for 3IO9
Entry DOI | 10.2210/pdb3io9/pdb |
Related | 2nl9 3IO8 |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION, ... (4 entities in total) |
Functional Keywords | apoptosis, alternative splicing, cytoplasm, developmental protein, differentiation, isopeptide bond, membrane, mitochondrion, nucleus, phosphoprotein, polymorphism, transmembrane, ubl conjugation |
Biological source | Mus musculus (Mouse) More |
Cellular location | Membrane ; Single-pass membrane protein : Q07820 Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521 |
Total number of polymer chains | 2 |
Total formula weight | 21813.93 |
Authors | Czabotar, P.E.,Lee, E.F.,Yang, H.,Sleebs, B.E.,Lessene, G.,Colman, P.M.,Smith, B.J.,Fairlie, W.D. (deposition date: 2009-08-14, release date: 2009-09-01, Last modification date: 2023-09-06) |
Primary citation | Lee, E.F.,Czabotar, P.E.,Yang, H.,Sleebs, B.E.,Lessene, G.,Colman, P.M.,Smith, B.J.,Fairlie, W.D. Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J.Biol.Chem., 284:30508-30517, 2009 Cited by PubMed: 19726685DOI: 10.1074/jbc.M109.040725 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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