3IO9

BimL12Y in complex with Mcl-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Induced myeloid leukemia cell differentiation protein Mcl-1	polymer	162	18227.6	1	UniProt (P97287) UniProt (Q07820) Pfam (PF00452) In PDB	Mus musculus (Mouse)	Bcl-2-related protein EAT/mcl1, mcl1/EAT, Bcl-2-like protein 3, Bcl2-L-3
2	B	Bcl-2-like protein 11	polymer	26	3324.7	1	UniProt (O43521) Pfam (PF08945) In PDB	Homo sapiens	Bcl2-L-11, Bcl2-interacting mediator of cell death
3	A, B	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4		water	water		18.0	66	Chemie (HOH)

Sequence modifications

A: 171 - 208 (UniProt: P97287)

PDB	External Database	Details
Gly 166	-	expression tag
Pro 167	-	expression tag
Leu 168	-	expression tag
Gly 169	-	expression tag
Ser 170	-	expression tag

A: 209 - 327 (UniProt: Q07820)
B: 51 - 76 (UniProt: O43521)

PDB	External Database	Details
Tyr 62	Leu 152	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21552.3
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	21813.9

*Water molecules are not included.