3IO9

BimL12Y in complex with Mcl-1

3IO9 の概要

• エントリーDOI: 10.2210/pdb3io9/pdb
• 関連するPDBエントリー: 2nl9 3IO8
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION, ... (4 entities in total)
• 機能のキーワード: apoptosis, alternative splicing, cytoplasm, developmental protein, differentiation, isopeptide bond, membrane, mitochondrion, nucleus, phosphoprotein, polymorphism, transmembrane, ubl conjugation
• 由来する生物種: Mus musculus (Mouse); 詳細
• 細胞内の位置: Membrane ; Single-pass membrane protein : Q07820; Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 21813.93

構造登録者

Czabotar, P.E.,Lee, E.F.,Yang, H.,Sleebs, B.E.,Lessene, G.,Colman, P.M.,Smith, B.J.,Fairlie, W.D. (登録日: 2009-08-14, 公開日: 2009-09-01, 最終更新日: 2023-09-06)

• 主引用文献: Lee, E.F.,Czabotar, P.E.,Yang, H.,Sleebs, B.E.,Lessene, G.,Colman, P.M.,Smith, B.J.,Fairlie, W.D.; Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.; J.Biol.Chem., 284:30508-30517, 2009; PubMed: 19726685; DOI: 10.1074/jbc.M109.040725

実験手法

X-RAY DIFFRACTION (2.4 Å)