3INV
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH, dUMP AND C-448 ANTIFOLATE
3INV の概要
エントリーDOI | 10.2210/pdb3inv/pdb |
関連するPDBエントリー | 2H2Q 3CL9 3CLB 3HBB 3IRM 3IRN 3IRO |
分子名称 | Bifunctional dihydrofolate reductase-thymidylate synthase, 1-[3-(2,3-dichlorophenoxy)propoxy]-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
機能のキーワード | dhfr-ts antifolate complex, methyltransferase, multifunctional enzyme, nadp, nucleotide biosynthesis, one-carbon metabolism, oxidoreductase, transferase, oxidoreductase-transferase complex, oxidoreductase/transferase |
由来する生物種 | Trypanosoma cruzi |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 121144.40 |
構造登録者 | |
主引用文献 | Chitnumsub, P.,Yuvaniyama, J.,Vilaivan, T.,Vanichtanankul, J.,Kamchonwongpaisan, S.,Yuthavong, Y. Structural basis of antifolate inhibition of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase To be Published, |
実験手法 | X-RAY DIFFRACTION (2.37 Å) |
構造検証レポート
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