3INM
Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+)
Summary for 3INM
Entry DOI | 10.2210/pdb3inm/pdb |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-OXOGLUTARIC ACID, ... (7 entities in total) |
Functional Keywords | rossmann fold, nadp, ketoglutarate, quaternary complex, oxidoreductase, glyoxylate bypass, magnesium, manganese, metal-binding, peroxisome, tricarboxylic acid cycle |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : O75874 |
Total number of polymer chains | 3 |
Total formula weight | 147547.10 |
Authors | Fontano, E.,Brown, R.S.,Suto, R.K.,Bhyravbhatla, B. (deposition date: 2009-08-12, release date: 2009-11-24, Last modification date: 2023-09-06) |
Primary citation | Dang, L.,White, D.W.,Gross, S.,Bennett, B.D.,Bittinger, M.A.,Driggers, E.M.,Fantin, V.R.,Jang, H.G.,Jin, S.,Keenan, M.C.,Marks, K.M.,Prins, R.M.,Ward, P.S.,Yen, K.E.,Liau, L.M.,Rabinowitz, J.D.,Cantley, L.C.,Thompson, C.B.,Vander Heiden, M.G.,Su, S.M. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature, 462:739-744, 2009 Cited by PubMed: 19935646DOI: 10.1038/nature08617 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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