3INM

Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+)

3INM の概要

• エントリーDOI: 10.2210/pdb3inm/pdb
• 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-OXOGLUTARIC ACID, ... (7 entities in total)
• 機能のキーワード: rossmann fold, nadp, ketoglutarate, quaternary complex, oxidoreductase, glyoxylate bypass, magnesium, manganese, metal-binding, peroxisome, tricarboxylic acid cycle
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : O75874
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 147547.10

構造登録者

Fontano, E.,Brown, R.S.,Suto, R.K.,Bhyravbhatla, B. (登録日: 2009-08-12, 公開日: 2009-11-24, 最終更新日: 2023-09-06)

• 主引用文献: Dang, L.,White, D.W.,Gross, S.,Bennett, B.D.,Bittinger, M.A.,Driggers, E.M.,Fantin, V.R.,Jang, H.G.,Jin, S.,Keenan, M.C.,Marks, K.M.,Prins, R.M.,Ward, P.S.,Yen, K.E.,Liau, L.M.,Rabinowitz, J.D.,Cantley, L.C.,Thompson, C.B.,Vander Heiden, M.G.,Su, S.M.; Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.; Nature, 462:739-744, 2009; PubMed: 19935646; DOI: 10.1038/nature08617

実験手法

X-RAY DIFFRACTION (2.1 Å)