3INB

Structure of the measles virus hemagglutinin bound to the CD46 receptor

3INB の概要

• エントリーDOI: 10.2210/pdb3inb/pdb
• 関連するPDBエントリー: 1CKL 2O39 2RKC 2ZB5 2ZB6
• 分子名称: Hemagglutinin glycoprotein, Membrane cofactor protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: measles, beta propeller, envelope protein, hemagglutinin, viral protein. membrane cofactor protein, mcp, cd46, virus receptor complex, scr, complement control protein, immune system complex, membrane, transmembrane, virion, cell membrane, glycoprotein, host-virus interaction, signal-anchor, complement pathway, disease mutation, disulfide bond, fertilization, immune response, innate immunity, phosphoprotein, sushi, viral protein, immune system, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Measles virus strain Edmonston (viruses); 詳細
• 細胞内の位置: Virion membrane; Single-pass type II membrane protein (Potential): P08362; Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein: P15529
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 133770.06

構造登録者

Santiago, C.,Celma, M.L.,Stehle, T.,Casasnovas, J.M. (登録日: 2009-08-12, 公開日: 2009-12-22, 最終更新日: 2024-11-20)

主引用文献

Santiago, C.,Celma, M.L.,Stehle, T.,Casasnovas, J.M.
Structure of the measles virus hemagglutinin bound to the CD46 receptor
Nat.Struct.Mol.Biol., 17:124-129, 2010

PubMed Abstract: The highly contagious measles virus infects millions of individuals worldwide, causing serious disease in children of developing countries. Infection is initiated by attachment of the measles virus hemagglutinin (MV-H), a glycoprotein anchored to the virus envelope, to the host cell receptors CD46 or signaling lymphocyte activation molecule (SLAM). Here we report the crystal structure of MV-H in complex with a CD46 protein spanning the two N-terminal domains. A unique groove at the side of the MV-H beta-propeller domain, which is absent in homologous paramyxovirus attachment proteins, engages residues in both CD46 domains. Key contacts involve a protruding loop in the N-terminal CD46 domain that carries two sequential proline residues (PP motif) and penetrates deeply into a hydrophobic socket in MV-H. We identify a similar PP motif in SLAM, defining a common measles virus recognition epitope in the CD46 and SLAM receptor proteins.

PubMed: 20010840
DOI: 10.1038/nsmb.1726

実験手法

X-RAY DIFFRACTION (3.1 Å)