3IN7
Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic
Summary for 3IN7
Entry DOI | 10.2210/pdb3in7/pdb |
Related | 2HUW 3C7I 3IMD 3IMJ 3IN8 |
Related PRD ID | PRD_000633 |
Descriptor | Growth factor receptor-bound protein 2, N~2~-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-D-glutaminyl-D-aspartamide (3 entities in total) |
Functional Keywords | ligand preorganization, peptide mimics, golgi apparatus, host-virus interaction, phosphoprotein, sh2 domain, sh3 domain, signaling protein-pseudopeptide ligand complex, signaling protein-peptide complex, signaling protein/peptide |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P62993 |
Total number of polymer chains | 2 |
Total formula weight | 28630.01 |
Authors | Clements, J.H. (deposition date: 2009-08-11, release date: 2009-11-17, Last modification date: 2023-09-06) |
Primary citation | Delorbe, J.E.,Clements, J.H.,Teresk, M.G.,Benfield, A.P.,Plake, H.R.,Millspaugh, L.E.,Martin, S.F. Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131:16758-16770, 2009 Cited by PubMed: 19886660DOI: 10.1021/ja904698q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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