3IN7
Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Growth factor receptor-bound protein 2 | polymer | 117 | 13758.5 | 2 | UniProt (P62993) Pfam (PF00017) In PDB | Homo sapiens (human) | Adapter protein GRB2, SH2/SH3 adapter GRB2, Protein Ash |
2 | A, C | N~2~-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-D-glutaminyl-D-aspartamide | non-polymer | 556.5 | 2 | BIRD (PRD_000633) Chemie (AYQ) | |||
3 | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A, C: 53 - 163 (UniProt: P62993)
PDB | External Database | Details |
---|---|---|
His 164 | - | expression tag |
His 165 | - | expression tag |
His 166 | - | expression tag |
His 167 | - | expression tag |
His 168 | - | expression tag |
His 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 27517.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1112.9 | |
All* | Total formula weight | 28630.0 |