3IMX

Crystal Structure of human glucokinase in complex with a synthetic activator

3IMX の概要

• エントリーDOI: 10.2210/pdb3imx/pdb
• 分子名称: Glucokinase, alpha-D-glucopyranose, (2R)-3-cyclopentyl-N-(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)-2-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}propanamide, ... (5 entities in total)
• 機能のキーワード: sugar kinase, atp-binding, glycolysis, kinase, nucleotide-binding, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51655.64

構造登録者

Stams, T.,Vash, B. (登録日: 2009-08-11, 公開日: 2009-10-06, 最終更新日: 2023-09-06)

• 主引用文献: Bebernitz, G.R.,Beaulieu, V.,Dale, B.A.,Deacon, R.,Duttaroy, A.,Gao, J.,Grondine, M.S.,Gupta, R.C.,Kakmak, M.,Kavana, M.,Kirman, L.C.,Liang, J.,Maniara, W.M.,Munshi, S.,Nadkarni, S.S.,Schuster, H.F.,Stams, T.,St Denny, I.,Taslimi, P.M.,Vash, B.,Caplan, S.L.; Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes.; J.Med.Chem., 52:6142-6152, 2009; PubMed: 19746978; DOI: 10.1021/jm900839k

実験手法

X-RAY DIFFRACTION (2 Å)