3IKM

Crystal structure of human mitochondrial DNA polymerase holoenzyme

Summary for 3IKM

Entry DOI	10.2210/pdb3ikm/pdb
Descriptor	DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2 (2 entities in total)
Functional Keywords	human mitochondrial dna polymerase, disease mutation, dna replication, dna-binding, dna-directed dna polymerase, magnesium, mitochondrion, neuropathy, nucleotidyltransferase, progressive external ophthalmoplegia, transferase, transit peptide
Biological source	Homo sapiens (human) More
Cellular location	Mitochondrion : P54098 Q9UHN1
Total number of polymer chains	6
Total formula weight	459800.98
Authors	Lee, Y.-S.,Kennedy, W.D.,Yin, Y.W. (deposition date: 2009-08-06, release date: 2009-11-03, Last modification date: 2024-02-21)
Primary citation	Lee, Y.S.,Kennedy, W.D.,Yin, Y.W. Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations. Cell(Cambridge,Mass.), 139:312-324, 2009 Cited by PubMed: 19837034 DOI: 10.1016/j.cell.2009.07.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.24 Å)

Structure validation