3IKM

Crystal structure of human mitochondrial DNA polymerase holoenzyme

3IKM の概要

• エントリーDOI: 10.2210/pdb3ikm/pdb
• 分子名称: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2 (2 entities in total)
• 機能のキーワード: human mitochondrial dna polymerase, disease mutation, dna replication, dna-binding, dna-directed dna polymerase, magnesium, mitochondrion, neuropathy, nucleotidyltransferase, progressive external ophthalmoplegia, transferase, transit peptide
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Mitochondrion : P54098 Q9UHN1
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 459800.98

構造登録者

Lee, Y.-S.,Kennedy, W.D.,Yin, Y.W. (登録日: 2009-08-06, 公開日: 2009-11-03, 最終更新日: 2024-02-21)

• 主引用文献: Lee, Y.S.,Kennedy, W.D.,Yin, Y.W.; Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations.; Cell(Cambridge,Mass.), 139:312-324, 2009; PubMed: 19837034; DOI: 10.1016/j.cell.2009.07.050

実験手法

X-RAY DIFFRACTION (3.24 Å)