Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3IK0

Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 7C1

Summary for 3IK0
Entry DOI10.2210/pdb3ik0/pdb
Related3BYX 3BZ0 3BZN 3C06 3C0A 3IJZ 3IK1
DescriptorThymidylate synthase, 4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenecarboximidamide, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (4 entities in total)
Functional Keywordstransferase, nucleotide synthase, methyltransferase, nucleotide biosynthesis
Biological sourceLactobacillus casei
Cellular locationCytoplasm: P00469
Total number of polymer chains1
Total formula weight37217.93
Authors
Pozzi, C.,Cancian, L.,Leone, R.,Luciani, R.,Ferrari, S.,Mangani, S.,Costi, M.P. (deposition date: 2009-08-05, release date: 2010-08-11, Last modification date: 2023-11-01)
Primary citationMangani, S.,Cancian, L.,Leone, R.,Pozzi, C.,Lazzari, S.,Luciani, R.,Ferrari, S.,Costi, M.P.
Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening
J.Med.Chem., 54:5454-5467, 2011
Cited by
PubMed: 21696158
DOI: 10.1021/jm2005018
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

數據於2024-03-27公開中

PDB statisticsPDBj update infoContact PDBjnumon