3IJO
Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide
Summary for 3IJO
Entry DOI | 10.2210/pdb3ijo/pdb |
Related | 3IJX 3IK6 3IL1 3ILT 3ILU |
Descriptor | Glutamate receptor 2, GLUTAMIC ACID, (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ... (5 entities in total) |
Functional Keywords | glutamate receptor, glur2, ampa receptor, neurotransmitter receptor, s1s2, allosteric modulator, alternative splicing, cell junction, cell membrane, endoplasmic reticulum, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphoprotein, postsynaptic cell membrane, receptor, rna editing, synapse, transmembrane, transport, membrane protein |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 3 |
Total formula weight | 88345.01 |
Authors | Ptak, C.P.,Ahmed, A.H.,Oswald, R.E. (deposition date: 2009-08-04, release date: 2009-09-15, Last modification date: 2023-09-06) |
Primary citation | Ptak, C.P.,Ahmed, A.H.,Oswald, R.E. Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48:8594-8602, 2009 Cited by PubMed: 19673491DOI: 10.1021/bi901127s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.003 Å) |
Structure validation
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