3IJO

Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide

3IJO の概要

• エントリーDOI: 10.2210/pdb3ijo/pdb
• 関連するPDBエントリー: 3IJX 3IK6 3IL1 3ILT 3ILU
• 分子名称: Glutamate receptor 2, GLUTAMIC ACID, (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ... (5 entities in total)
• 機能のキーワード: glutamate receptor, glur2, ampa receptor, neurotransmitter receptor, s1s2, allosteric modulator, alternative splicing, cell junction, cell membrane, endoplasmic reticulum, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphoprotein, postsynaptic cell membrane, receptor, rna editing, synapse, transmembrane, transport, membrane protein
• 由来する生物種: Rattus norvegicus (rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 88345.01

構造登録者

Ptak, C.P.,Ahmed, A.H.,Oswald, R.E. (登録日: 2009-08-04, 公開日: 2009-09-15, 最終更新日: 2023-09-06)

• 主引用文献: Ptak, C.P.,Ahmed, A.H.,Oswald, R.E.; Probing the allosteric modulator binding site of GluR2 with thiazide derivatives; Biochemistry, 48:8594-8602, 2009; PubMed: 19673491; DOI: 10.1021/bi901127s

実験手法

X-RAY DIFFRACTION (2.003 Å)