3IJJ

Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer)

3IJJ の概要

• エントリーDOI: 10.2210/pdb3ijj/pdb
• 関連するPDBエントリー: 1CA7 3IJG
• 分子名称: Macrophage migration inhibitory factor, (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ... (6 entities in total)
• 機能のキーワード: allosteric inhibition, cytokine, immune response, inflammatory response, innate immunity, isomerase, phosphoprotein, secreted
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted : P14174
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 38661.03

構造登録者

Crichlow, G.V.,Cho, Y.,Lolis, E.J. (登録日: 2009-08-04, 公開日: 2010-06-16, 最終更新日: 2023-09-06)

• 主引用文献: Cho, Y.,Crichlow, G.V.,Vermeire, J.J.,Leng, L.,Du, X.,Hodsdon, M.E.,Bucala, R.,Cappello, M.,Gross, M.,Gaeta, F.,Johnson, K.,Lolis, E.J.; Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.; Proc.Natl.Acad.Sci.USA, 107:11313-11318, 2010; PubMed: 20534506; DOI: 10.1073/pnas.1002716107

実験手法

X-RAY DIFFRACTION (1.25 Å)