3IEO
The coumarin-binding site in carbonic anhydrase: the antiepileptic lacosamide as an example
Summary for 3IEO
Entry DOI | 10.2210/pdb3ieo/pdb |
Related | 3F8E |
Descriptor | Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (6 entities in total) |
Functional Keywords | carbonic anhydrase, antiepilectic, disease mutation, lyase, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30128.07 |
Authors | Temperini, C.,Innocenti, A.,Scozzafava, A.,Parkkila, S.,Supuran, C.T. (deposition date: 2009-07-23, release date: 2010-01-26, Last modification date: 2023-11-01) |
Primary citation | Temperini, C.,Innocenti, A.,Scozzafava, A.,Parkkila, S.,Supuran, C.T. The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors J.Med.Chem., 53:850-854, 2010 Cited by PubMed: 20028100DOI: 10.1021/jm901524f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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