3IEC

Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates

3IEC の概要

• エントリーDOI: 10.2210/pdb3iec/pdb
• 分子名称: Serine/threonine-protein kinase MARK2, Cytotoxicity-associated immunodominant antigen (3 entities in total)
• 機能のキーワード: protein-protein complex, kinase, virulence factor, alternative promoter usage, atp-binding, cell membrane, developmental protein, differentiation, magnesium, membrane, metal-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, signaling protein-toxin complex, signaling protein/toxin
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Peripheral membrane protein: Q7KZI7
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 201371.44

構造登録者

Stebbins, C.E.,Nesic, D.,Miller, M. (登録日: 2009-07-22, 公開日: 2009-12-08, 最終更新日: 2024-02-21)

• 主引用文献: Nesic, D.,Miller, M.C.,Quinkert, Z.T.,Stein, M.,Chait, B.T.,Stebbins, C.E.; Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.; Nat.Struct.Mol.Biol., 17:130-132, 2010; PubMed: 19966800; DOI: 10.1038/nsmb.1705

実験手法

X-RAY DIFFRACTION (2.2 Å)