3IE3
Structural basis for the binding of the anti-cancer compound 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) to human glutathione S-transferases
Summary for 3IE3
Entry DOI | 10.2210/pdb3ie3/pdb |
Related | 3GUR 3GUS |
Descriptor | Glutathione S-transferase P, GLUTATHIONE, 6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]hexan-1-ol, ... (5 entities in total) |
Functional Keywords | detoxification, multidrug resistance, cancer treatment, phosphoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 48008.76 |
Authors | Federici, L.,Lo Sterzo, C.,Di Matteo, A.,Scaloni, F.,Federici, G.,Caccuri, A.M. (deposition date: 2009-07-22, release date: 2009-10-27, Last modification date: 2023-11-01) |
Primary citation | Federici, L.,Lo Sterzo, C.,Pezzola, S.,Di Matteo, A.,Scaloni, F.,Federici, G.,Caccuri, A.M. Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases Cancer Res., 69:8025-8034, 2009 Cited by PubMed: 19808963DOI: 10.1158/0008-5472.CAN-09-1314 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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