3IE3

Structural basis for the binding of the anti-cancer compound 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) to human glutathione S-transferases

3IE3 の概要

• エントリーDOI: 10.2210/pdb3ie3/pdb
• 関連するPDBエントリー: 3GUR 3GUS
• 分子名称: Glutathione S-transferase P, GLUTATHIONE, 6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]hexan-1-ol, ... (5 entities in total)
• 機能のキーワード: detoxification, multidrug resistance, cancer treatment, phosphoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48008.76

構造登録者

Federici, L.,Lo Sterzo, C.,Di Matteo, A.,Scaloni, F.,Federici, G.,Caccuri, A.M. (登録日: 2009-07-22, 公開日: 2009-10-27, 最終更新日: 2023-11-01)

• 主引用文献: Federici, L.,Lo Sterzo, C.,Pezzola, S.,Di Matteo, A.,Scaloni, F.,Federici, G.,Caccuri, A.M.; Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases; Cancer Res., 69:8025-8034, 2009; PubMed: 19808963; DOI: 10.1158/0008-5472.CAN-09-1314

実験手法

X-RAY DIFFRACTION (1.8 Å)