3ICC

Crystal structure of a putative 3-oxoacyl-(acyl carrier protein) reductase from Bacillus anthracis at 1.87 A resolution

Summary for 3ICC

• Entry DOI: 10.2210/pdb3icc/pdb
• Descriptor: Putative 3-oxoacyl-(acyl carrier protein) reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• Functional Keywords: structural genomics, putative 3-oxoacyl-(acyl carrier protein) reductase, oxidoreductase, center for structural genomics of infectious diseases, csgid
• Biological source: Bacillus anthracis str. 'Ames Ancestor' (anthrax bacterium)
• Total number of polymer chains: 2
• Total formula weight: 57374.38

Authors

Hou, J.,Chruszcz, M.,Zheng, H.,Cymborowski, M.,Luo, H.-B.,Skarina, T.,Gordon, S.,Savchenko, A.,Edwards, A.M.,Anderson, W.,Minor, W.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2009-07-17, release date: 2009-07-28, Last modification date: 2024-11-27)

Primary citation

Hou, J.,Wojciechowska, K.,Zheng, H.,Chruszcz, M.,Cooper, D.R.,Cymborowski, M.,Skarina, T.,Gordon, E.,Luo, H.,Savchenko, A.,Minor, W.
Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis.
Acta Crystallogr.,Sect.F, 68:632-637, 2012

PubMed Abstract: The crystal structure of a short-chain dehydrogenase/reductase from Bacillus anthracis strain `Ames Ancestor' complexed with NADP has been determined and refined to 1.87 Å resolution. The structure of the enzyme consists of a Rossmann fold composed of seven parallel β-strands sandwiched by three α-helices on each side. An NADP molecule from an endogenous source is bound in the conserved binding pocket in the syn conformation. The loop region responsible for binding another substrate forms two perpendicular short helices connected by a sharp turn.

PubMed: 22684058
DOI: 10.1107/S1744309112017939

Experimental method

X-RAY DIFFRACTION (1.87 Å)