3I9J

Crystal structure of ADP ribosyl cyclase complexed with a substrate analog and a product nicotinamide

Summary for 3I9J

• Entry DOI: 10.2210/pdb3i9j/pdb
• Related: 3I9K 3I9L 3I9M 3I9N
• Descriptor: ADP-ribosyl cyclase, Nicotinamide 2-fluoro-adenine dinucleotide, [(2R,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ... (5 entities in total)
• Functional Keywords: homodimer, enzyme-analog-nicotinamide complex, adp-ribosyl cyclase, disulfide bond, fertilization, hydrolase, nad
• Biological source: Aplysia californica (California sea hare)
• Cellular location: Cytoplasmic vesicle: P29241
• Total number of polymer chains: 2
• Total formula weight: 60524.74

Authors

Liu, Q.,Graeff, R.,Kriksunov, I.A.,Jiang, H.,Zhang, B.,Oppenheimer, N.,Lin, H.,Potter, B.V.L.,Lee, H.C.,Hao, Q. (deposition date: 2009-07-12, release date: 2009-07-28, Last modification date: 2023-11-01)

• Primary citation: Liu, Q.,Graeff, R.,Kriksunov, I.A.,Jiang, H.,Zhang, B.,Oppenheimer, N.,Lin, H.,Potter, B.V.L.,Lee, H.C.,Hao, Q.; Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase; J.Biol.Chem., 284:27637-27645, 2009; PubMed: 19640846; DOI: 10.1074/jbc.M109.031005

Experimental method

X-RAY DIFFRACTION (2.18 Å)