3I8A
Staphylococcus aureus H30N, F98Y Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)
Summary for 3I8A
Entry DOI | 10.2210/pdb3i8a/pdb |
Related | 3FQ0 3FQO |
Descriptor | Dihydrofolate reductase, 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | nadph, one-carbon metabolism, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 19065.30 |
Authors | Frey, K.M.,Lombardo, M.N.,Anderson, A.C. (deposition date: 2009-07-09, release date: 2010-02-09, Last modification date: 2023-09-06) |
Primary citation | Frey, K.M.,Lombardo, M.N.,Wright, D.L.,Anderson, A.C. Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase. J.Struct.Biol., 170:93-97, 2010 Cited by PubMed: 20026215DOI: 10.1016/j.jsb.2009.12.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
Download full validation report