3I8A

Staphylococcus aureus H30N, F98Y Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)

Summary for 3I8A

Entry DOI	10.2210/pdb3i8a/pdb
Related	3FQ0 3FQO
Descriptor	Dihydrofolate reductase, 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywords	nadph, one-carbon metabolism, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	19065.30
Authors	Frey, K.M.,Lombardo, M.N.,Anderson, A.C. (deposition date: 2009-07-09, release date: 2010-02-09, Last modification date: 2023-09-06)
Primary citation	Frey, K.M.,Lombardo, M.N.,Wright, D.L.,Anderson, A.C. Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase. J.Struct.Biol., 170:93-97, 2010 Cited by PubMed: 20026215 DOI: 10.1016/j.jsb.2009.12.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation