3I7Z

Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step

3I7Z の概要

• エントリーDOI: 10.2210/pdb3i7z/pdb
• 関連するPDBエントリー: 1A5Y 1PTU 2CM2 2HNQ 3I80
• 分子名称: Tyrosine-protein phosphatase non-receptor type 1, EGFR receptor fragment, VANADATE ION, ... (6 entities in total)
• 機能のキーワード: hydrolase, p-loop, wpd-loop, protein phosphatase, egfr receptor, vanadate, acetylation, endoplasmic reticulum, membrane, oxidation, phosphoprotein, polymorphism
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38633.76

構造登録者

Brandao, T.A.S.,Johnson, S.J.,Hengge, A.C. (登録日: 2009-07-09, 公開日: 2010-03-16, 最終更新日: 2023-09-06)

• 主引用文献: Brandao, T.A.,Hengge, A.C.,Johnson, S.J.; Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps.; J.Biol.Chem., 285:15874-15883, 2010; PubMed: 20236928; DOI: 10.1074/jbc.M109.066951

実験手法

X-RAY DIFFRACTION (2.3 Å)