3I6W
Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase
3I6W の概要
エントリーDOI | 10.2210/pdb3i6w/pdb |
分子名称 | Serine/threonine-protein kinase Chk2 (1 entity in total) |
機能のキーワード | ser/thr protein kinase, fha domain, atp-binding, cell cycle, disease mutation, kinase, li-fraumeni syndrome, magnesium, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017 |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 406719.56 |
構造登録者 | |
主引用文献 | Cai, Z.,Chehab, N.H.,Pavletich, N.P. Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase. Mol.Cell, 35:818-829, 2009 Cited by PubMed: 19782031DOI: 10.1016/j.molcel.2009.09.007 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.25 Å) |
構造検証レポート
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