3I6R

Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM74

3I6R の概要

• エントリーDOI: 10.2210/pdb3i6r/pdb
• 関連するPDBエントリー: 3I65 3I68
• 分子名称: Dihydroorotate dehydrogenase homolog, mitochondrial, 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, FLAVIN MONONUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: plasmodium falciparum, dihydroorotate dehydrogenase, triazolopyrimidine, inhibitor, dsm74, fad, flavoprotein, membrane, mitochondrion, mitochondrion inner membrane, oxidoreductase, pyrimidine biosynthesis, transit peptide
• 由来する生物種: Plasmodium falciparum 3D7
• 細胞内の位置: Mitochondrion inner membrane (By similarity); Single-pass membrane protein (Potential): Q08210
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47558.03

構造登録者

Deng, X.,Phillips, M.A. (登録日: 2009-07-07, 公開日: 2009-07-28, 最終更新日: 2023-09-06)

• 主引用文献: Deng, X.,Gujjar, R.,El Mazouni, F.,Kaminsky, W.,Malmquist, N.A.,Goldsmith, E.J.,Rathod, P.K.,Phillips, M.A.; Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.; J.Biol.Chem., 284:26999-27009, 2009; PubMed: 19640844; DOI: 10.1074/jbc.M109.028589

実験手法

X-RAY DIFFRACTION (2.5 Å)