3I5N

Crystal structure of c-Met with triazolopyridazine inhibitor 13

3I5N の概要

• エントリーDOI: 10.2210/pdb3i5n/pdb
• 関連するPDBエントリー: 3CD8
• 分子名称: Hepatocyte growth factor receptor, 7-methoxy-N-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-1,5-naphthyridin-4-amine (3 entities in total)
• 機能のキーワード: proto-oncogene, rtk, receptor tyrosine kinase, scatter factor receptor, hgf/sf, alternative splicing, atp-binding, chromosomal rearrangement, disease mutation, disulfide bond, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35599.12

構造登録者

Bellon, S.F.,Whittington, D.A.,Long, A.M.,Boezio, A.A. (登録日: 2009-07-06, 公開日: 2010-01-12, 最終更新日: 2023-09-06)

• 主引用文献: Boezio, A.A.,Berry, L.,Albrecht, B.K.,Bauer, D.,Bellon, S.F.,Bode, C.,Chen, A.,Choquette, D.,Dussault, I.,Hirai, S.,Kaplan-Lefko, P.,Larrow, J.F.,Lin, M.H.,Lohman, J.,Potashman, M.H.,Rex, K.,Santostefano, M.,Shah, K.,Shimanovich, R.,Springer, S.K.,Teffera, Y.,Yang, Y.,Zhang, Y.,Harmange, J.C.; Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors; Bioorg.Med.Chem.Lett., 19:6307-6312, 2009; PubMed: 19819693; DOI: 10.1016/j.bmcl.2009.09.096

実験手法

X-RAY DIFFRACTION (2 Å)