3I55

Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit

3I55 の概要

• エントリーDOI: 10.2210/pdb3i55/pdb
• 関連するPDBエントリー: 3I56
• 分子名称: 23S ribosomal RNA, 50S ribosomal protein L11P, 50S ribosomal protein L13P, ... (40 entities in total)
• 機能のキーワード: large ribosomal subunit, mycalamide a, ribonucleoprotein, ribosomal protein, rna-binding, rrna-binding, trna-binding, metal-binding, zinc-finger, ribosome-antibiotic complex, ribosome/antibiotic
• 由来する生物種: Haloarcula marismortui ATCC 43049; 詳細
• 細胞内の位置: Cytoplasm : P12743
• タンパク質・核酸の鎖数: 32
• 化学式量合計: 1495041.75

構造登録者

Gurel, G.,Blaha, G.,Steitz, T.A.,Moore, P.B. (登録日: 2009-07-03, 公開日: 2010-03-09, 最終更新日: 2024-02-21)

主引用文献

Gurel, G.,Blaha, G.,Steitz, T.A.,Moore, P.B.
Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui.
Antimicrob.Agents Chemother., 53:5010-5014, 2009

PubMed Abstract: Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.

PubMed: 19738021
DOI: 10.1128/AAC.00817-09

実験手法

X-RAY DIFFRACTION (3.11 Å)