3I3J

Crystal Structure of the Bromodomain of Human EP300

3I3J の概要

• エントリーDOI: 10.2210/pdb3i3j/pdb
• 分子名称: Histone acetyltransferase p300, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• 機能のキーワード: structural genomics bromodomain, p300, consortium, sgc, structural genomics consortium, bromodomain, cell cycle, citrullination, disease mutation, host-virus interaction, metal-binding, methylation, nucleus, phosphoprotein, transcription, transcription regulation, transferase, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q09472
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 176332.74

構造登録者

Filippakopoulos, P.,Picaud, S.,Phillips, C.,Pike, A.C.W.,Muniz, J.,Roos, A.,Chaikuad, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2009-06-30, 公開日: 2009-07-28, 最終更新日: 2023-11-01)

• 主引用文献: Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S.; Histone recognition and large-scale structural analysis of the human bromodomain family.; Cell(Cambridge,Mass.), 149:214-231, 2012; PubMed: 22464331; DOI: 10.1016/j.cell.2012.02.013

実験手法

X-RAY DIFFRACTION (2.33 Å)