3I0S
crystal structure of HIV reverse transcriptase in complex with inhibitor 7
Summary for 3I0S
Entry DOI | 10.2210/pdb3i0s/pdb |
Related | 3I0R |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, S-{2-[(2-chloro-4-sulfamoylphenyl)amino]-2-oxoethyl} 6,8-dichloro-3,4-dihydroquinoline-1(2H)-carbothioate (3 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltrasferase, aids, aspartyl protease, capsid maturation, capsid protein, cell membrane, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, host-virus interaction, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, ribosomal frameshifting, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger |
Biological source | HIV-1 M:B_HXB2R (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 117135.56 |
Authors | Yan, Y.,Prasad, S. (deposition date: 2009-06-25, release date: 2009-08-25, Last modification date: 2023-09-06) |
Primary citation | Su, D.S.,Lim, J.J.,Tinney, E.,Wan, B.L.,Young, M.B.,Anderson, K.D.,Rudd, D.,Munshi, V.,Bahnck, C.,Felock, P.J.,Lu, M.,Lai, M.T.,Touch, S.,Moyer, G.,Distefano, D.J.,Flynn, J.A.,Liang, Y.,Sanchez, R.,Prasad, S.,Yan, Y.,Perlow-Poehnelt, R.,Torrent, M.,Miller, M.,Vacca, J.P.,Williams, T.M.,Anthony, N.J. Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants. Bioorg.Med.Chem.Lett., 19:5119-5123, 2009 Cited by PubMed: 19631528DOI: 10.1016/j.bmcl.2009.07.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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