3I08
Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR)
3I08 の概要
エントリーDOI | 10.2210/pdb3i08/pdb |
関連するPDBエントリー | 2oo4 3eto |
分子名称 | Neurogenic locus notch homolog protein 1, CALCIUM ION, CHLORIDE ION, ... (5 entities in total) |
機能のキーワード | sea domain, lin-12 notch repeat, lnr, heterodimerization domain, hd, activator, ank repeat, calcium, cell membrane, developmental protein, differentiation, disulfide bond, egf-like domain, glycoprotein, membrane, metal-binding, notch signaling pathway, nucleus, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, transmembrane, furin, t-all, leukemia, oncogene, metalloprotease, gamma-secretase, signaling protein |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity): P46531 P46531 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 64233.06 |
構造登録者 | |
主引用文献 | Gordon, W.R.,Vardar-Ulu, D.,L'Heureux, S.,Ashworth, T.,Malecki, M.J.,Sanchez-Irizarry, C.,McArthur, D.G.,Histen, G.,Mitchell, J.L.,Aster, J.C.,Blacklow, S.C. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. Plos One, 4:e6613-e6613, 2009 Cited by PubMed: 19701457DOI: 10.1371/journal.pone.0006613 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.2 Å) |
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