3I03

Crystal structure of bothropstoxin-I chemically modified by p-bromophenacyl bromide (BPB) - monomeric form at a high resolution

3I03 の概要

• エントリーDOI: 10.2210/pdb3i03/pdb
• 関連するPDBエントリー: 1Y4L 2Q2J 3CXI 3CYL 3HZD 3HZW
• 分子名称: Phospholipase A2 homolog bothropstoxin-1, p-Bromophenacyl bromide, ISOPROPYL ALCOHOL, ... (4 entities in total)
• 機能のキーワード: lys49-pla2s, phospholipase homologue, bothropstoxin-i, p-bromophenacyl bromide, myotoxicity, antibiotic, antimicrobial, disulfide bond, myotoxin, secreted, toxin
• 由来する生物種: Bothrops jararacussu (snake)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14091.17

構造登録者

Marchi-Salvador, D.P.,Fernandes, C.A.H.,Soares, A.M.,Fontes, M.R.M. (登録日: 2009-06-24, 公開日: 2010-05-12, 最終更新日: 2023-09-06)

• 主引用文献: Fernandes, C.A.,Marchi-Salvador, D.P.,Salvador, G.M.,Silva, M.C.,Costa, T.R.,Soares, A.M.,Fontes, M.R.; Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca(2+)-binding loop region for the catalytically inactive Lys49-PLA(2)s.; J.Struct.Biol., 171:31-43, 2010; PubMed: 20371382; DOI: 10.1016/j.jsb.2010.03.019

実験手法

X-RAY DIFFRACTION (1.48 Å)