3HZC
Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor
Summary for 3HZC
| Entry DOI | 10.2210/pdb3hzc/pdb |
| Related | 3FSM 3HAU 3HAW 3HBO 3HDK 3HLO |
| Related PRD ID | PRD_000398 |
| Descriptor | [Gly51;Aib51'] 'covalent dimer' HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide (3 entities in total) |
| Functional Keywords | asymmetric dimer, covalent dimer, beta-sheet, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Total number of polymer chains | 1 |
| Total formula weight | 22690.69 |
| Authors | Torbeev, V.Y.,Kent, S.B.H. (deposition date: 2009-06-23, release date: 2011-04-27, Last modification date: 2023-11-22) |
| Primary citation | Torbeev, V.Y.,Kent, S.B.H. Hydrogen bonds at the protein-inhibitor interface in the HIV-1 protease / inhibitors complexes probed by total chemical synthesis and X-ray crystallography To be Published, |
| Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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