3HY7

Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat

Summary for 3HY7

Entry DOI	10.2210/pdb3hy7/pdb
Related	3B8Z 3HY9 3HYG
Descriptor	A disintegrin and metalloproteinase with thrombospondin motifs 5, (2S,3R)-N~4~-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide, ZINC ION, ... (5 entities in total)
Functional Keywords	alpha/beta structure, central five stranded beta-sheet, cleavage on pair of basic residues, disulfide bond, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : Q9UNA0
Total number of polymer chains	2
Total formula weight	49907.39
Authors	Shieh, H.-S.,Williams, J.M.,Caspers, N.,Mathis, K.J.,Tortorella, M.D.,Tomasselli, A. (deposition date: 2009-06-22, release date: 2009-07-07, Last modification date: 2023-09-06)
Primary citation	Tortorella, M.D.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Munie, G.,Williams, J.M.,Caspers, N.,Wittwer, A.J.,Malfait, A.M.,Shieh, H.S. Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors J.Biol.Chem., 284:24185-24191, 2009 Cited by PubMed: 19586907 DOI: 10.1074/jbc.M109.029116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation