3HY7
Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | A disintegrin and metalloproteinase with thrombospondin motifs 5 | polymer | 221 | 24436.6 | 2 | UniProt (Q9UNA0) Pfam (PF01421) | Homo sapiens (human) | ADAMTS-5, ADAM-TS 5, ADAM-TS5, Aggrecanase-2, ADMP-2, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAMTS-11, ADAM-TS 11 |
| 2 | C, H (A, B) | (2S,3R)-N~4~-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide | non-polymer | 331.4 | 2 | Chemie (097) | |||
| 3 | D, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, F, G, J, K... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 5 | M, N (A, B) | water | water | 18.0 | 537 | Chemie (HOH) |
Sequence modifications
A, B: 262 - 480 (UniProt: Q9UNA0)
| PDB | External Database | Details |
|---|---|---|
| Met 260 | - | expression tag |
| Ala 261 | - | expression tag |
| Lys 282 | Leu 282 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48873.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1034.1 | |
| All* | Total formula weight | 49907.4 |
