Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3HY7

Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat

3HY7 の概要
エントリーDOI10.2210/pdb3hy7/pdb
関連するPDBエントリー3B8Z 3HY9 3HYG
分子名称A disintegrin and metalloproteinase with thrombospondin motifs 5, (2S,3R)-N~4~-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide, ZINC ION, ... (5 entities in total)
機能のキーワードalpha/beta structure, central five stranded beta-sheet, cleavage on pair of basic residues, disulfide bond, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
由来する生物種Homo sapiens (human)
細胞内の位置Secreted, extracellular space, extracellular matrix : Q9UNA0
タンパク質・核酸の鎖数2
化学式量合計49907.39
構造登録者
Shieh, H.-S.,Williams, J.M.,Caspers, N.,Mathis, K.J.,Tortorella, M.D.,Tomasselli, A. (登録日: 2009-06-22, 公開日: 2009-07-07, 最終更新日: 2023-09-06)
主引用文献Tortorella, M.D.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Munie, G.,Williams, J.M.,Caspers, N.,Wittwer, A.J.,Malfait, A.M.,Shieh, H.S.
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
J.Biol.Chem., 284:24185-24191, 2009
Cited by
PubMed: 19586907
DOI: 10.1074/jbc.M109.029116
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.69 Å)
構造検証レポート
Validation report summary of 3hy7
検証レポート(詳細版)ダウンロードをダウンロード

225158

件を2024-09-18に公開中

PDB statisticsPDBj update infoContact PDBjnumon