3HY7

Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with Marimastat

3HY7 の概要

• エントリーDOI: 10.2210/pdb3hy7/pdb
• 関連するPDBエントリー: 3B8Z 3HY9 3HYG
• 分子名称: A disintegrin and metalloproteinase with thrombospondin motifs 5, (2S,3R)-N~4~-[(1S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide, ZINC ION, ... (5 entities in total)
• 機能のキーワード: alpha/beta structure, central five stranded beta-sheet, cleavage on pair of basic residues, disulfide bond, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix : Q9UNA0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49907.39

構造登録者

Shieh, H.-S.,Williams, J.M.,Caspers, N.,Mathis, K.J.,Tortorella, M.D.,Tomasselli, A. (登録日: 2009-06-22, 公開日: 2009-07-07, 最終更新日: 2023-09-06)

• 主引用文献: Tortorella, M.D.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Munie, G.,Williams, J.M.,Caspers, N.,Wittwer, A.J.,Malfait, A.M.,Shieh, H.S.; Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors; J.Biol.Chem., 284:24185-24191, 2009; PubMed: 19586907; DOI: 10.1074/jbc.M109.029116

実験手法

X-RAY DIFFRACTION (1.69 Å)