3HY3

Structure of human MTHFS with 10-formyltetrahydrofolate

Summary for 3HY3

Entry DOI	10.2210/pdb3hy3/pdb
Related	3HXT 3HY4 3HY6
Descriptor	5-formyltetrahydrofolate cyclo-ligase, N-({4-[{[(2R,4S,4aR,6S,8aS)-2-amino-4-hydroxydecahydropteridin-6-yl]methyl}(formyl)amino]phenyl}carbonyl)-D-glutamic acid, NICKEL (II) ION, ... (5 entities in total)
Functional Keywords	antifolate, cancer, 10-formyltetrahydrofolate, atp-binding, folate-binding, ligase, magnesium, nucleotide-binding
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P49914
Total number of polymer chains	1
Total formula weight	24105.31
Authors	Wu, D.,Li, Y.,Song, G.,Cheng, C.,Shaw, N.,Liu, Z.-J. (deposition date: 2009-06-22, release date: 2009-07-14, Last modification date: 2023-11-01)
Primary citation	Wu, D.,Li, Y.,Song, G.,Cheng, C.,Zhang, R.,Joachimiak, A.,Shaw, N.,Liu, Z.-J. Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69:7294-7301, 2009 Cited by PubMed: 19738041 DOI: 10.1158/0008-5472.CAN-09-1927 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation