3HY3

Structure of human MTHFS with 10-formyltetrahydrofolate

3HY3 の概要

• エントリーDOI: 10.2210/pdb3hy3/pdb
• 関連するPDBエントリー: 3HXT 3HY4 3HY6
• 分子名称: 5-formyltetrahydrofolate cyclo-ligase, N-({4-[{[(2R,4S,4aR,6S,8aS)-2-amino-4-hydroxydecahydropteridin-6-yl]methyl}(formyl)amino]phenyl}carbonyl)-D-glutamic acid, NICKEL (II) ION, ... (5 entities in total)
• 機能のキーワード: antifolate, cancer, 10-formyltetrahydrofolate, atp-binding, folate-binding, ligase, magnesium, nucleotide-binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P49914
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24105.31

構造登録者

Wu, D.,Li, Y.,Song, G.,Cheng, C.,Shaw, N.,Liu, Z.-J. (登録日: 2009-06-22, 公開日: 2009-07-14, 最終更新日: 2023-11-01)

• 主引用文献: Wu, D.,Li, Y.,Song, G.,Cheng, C.,Zhang, R.,Joachimiak, A.,Shaw, N.,Liu, Z.-J.; Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues; Cancer Res., 69:7294-7301, 2009; PubMed: 19738041; DOI: 10.1158/0008-5472.CAN-09-1927

実験手法

X-RAY DIFFRACTION (1.8 Å)