3HWN

CATHEPSIN L with AZ13010160

Summary for 3HWN

Entry DOI	10.2210/pdb3hwn/pdb
Descriptor	Cathepsin L1, Nalpha-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)carbonyl]-N-[(2E)-2-iminoethyl]-3-{5-[(Z)-iminomethyl]-1,3,4-oxadiazol-2-yl}-L-phenylalaninamide (3 entities in total)
Functional Keywords	cathepsin l, drug design, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P07711
Total number of polymer chains	4
Total formula weight	116573.32
Authors	Kenny, P.,Morley, A. (deposition date: 2009-06-18, release date: 2009-09-15, Last modification date: 2021-10-13)
Primary citation	Bethel, P.A.,Gerhardt, S.,Jones, E.V.,Kenny, P.W.,Karoutchi, G.I.,Morley, A.D.,Oldham, K.,Rankine, N.,Augustin, M.,Krapp, S.,Simader, H.,Steinbacher, S. Design of selective Cathepsin inhibitors Bioorg.Med.Chem.Lett., 19:4622-4625, 2009 Cited by PubMed: 19616430 DOI: 10.1016/j.bmcl.2009.06.090 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation