3HW1

Structure of Bace (beta secretase) in complex with ligand EV2

Summary for 3HW1

Entry DOI	10.2210/pdb3hw1/pdb
Related	3HVG
Descriptor	Beta-secretase 1, 3-pyrrolidin-1-ylquinoxalin-2-amine, GLYCEROL, ... (4 entities in total)
Functional Keywords	protease, alzheimer's disease, aspartic protease, aspartyl protease, base, beta-secretase, glycoprotein, hydrolase, memapsin 2, amyloid precursor protein secretases, aspartic endopeptidases, fragment-based drug design, fluorescence polarisation, disulfide bond, transmembrane, zymogen
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	3
Total formula weight	138118.01
Authors	Godemann, R.,Madden, J.,Kramer, J.,Smith, M.A.,Barker, J.,Ebneth, A. (deposition date: 2009-06-17, release date: 2009-11-03, Last modification date: 2023-11-01)
Primary citation	Godemann, R.,Madden, J.,Kramer, J.,Smith, M.A.,Fritz, U.,Hesterkamp, T.,Barker, J.,Hoeppner, S.,Hallett, D.,Cesura, A.,Ebneth, A.,Kemp, J. Fragment-Based Discovery of BACE1 Inhibitors Using Functional Assays Biochemistry, 48:10743-10751, 2009 Cited by PubMed: 19799414 DOI: 10.1021/bi901061a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation