3HP6

Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus F710Y mutant bound to G:T mismatch

3HP6 の概要

• エントリーDOI: 10.2210/pdb3hp6/pdb
• 関連するPDBエントリー: 3HPO 3HT3
• 関連するBIRD辞書のPRD_ID: PRD_900003
• 分子名称: DNA polymerase I, large fragment, 5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*(DDG))-3', 5'-D(*AP*CP*GP*CP*CP*GP*TP*GP*AP*TP*CP*G)-3', ... (8 entities in total)
• 機能のキーワード: protein-dna complex, dna polymerase i, dna replication, dna-binding, dna-directed dna polymerase, hydrolase, nuclease, nucleotidyltransferase, transferase, transferase-dna complex, transferase/dna
• 由来する生物種: Geobacillus stearothermophilus; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 147172.06

構造登録者

Wu, E.Y.,Beese, L.S. (登録日: 2009-06-03, 公開日: 2010-06-23, 最終更新日: 2023-09-06)

• 主引用文献: Wu, E.Y.,Beese, L.S.; The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.; J.Biol.Chem., 286:19758-19767, 2011; PubMed: 21454515; DOI: 10.1074/jbc.M110.191130

実験手法

X-RAY DIFFRACTION (1.81 Å)