3HO0

Crystal structure of the PPARgamma-LBD complexed with a new aryloxy-3phenylpropanoic acid

Summary for 3HO0

Entry DOI	10.2210/pdb3ho0/pdb
Related	3B3K 3HOD
Descriptor	Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-phenethylphenoxy)-3-phenyl-propanoic acid (3 entities in total)
Functional Keywords	bundle of alpha-helices, small four-stranded beta-sheet, transcription, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription regulation, zinc, zinc-finger
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	65407.72
Authors	Pochetti, G.,Montanari, R.,Mazza, F.,Loiodice, F.,Fracchiolla, G.,Laghezza, A.,Lavecchia, A.,Novellino, E. (deposition date: 2009-06-01, release date: 2009-10-27, Last modification date: 2023-11-01)
Primary citation	Fracchiolla, G.,Laghezza, A.,Piemontese, L.,Tortorella, P.,Mazza, F.,Montanari, R.,Pochetti, G.,Lavecchia, A.,Novellino, E.,Pierno, S.,Conte Camerino, D.,Loiodice, F. New 2-Aryloxy-3-phenyl-propanoic Acids As Peroxisome Proliferator-Activated Receptors alpha/gamma Dual Agonists with Improved Potency and Reduced Adverse Effects on Skeletal Muscle Function J.Med.Chem., 52:6382-6393, 2009 Cited by PubMed: 19775169 DOI: 10.1021/jm900941b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation