3HNG

Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide

3HNG の概要

• エントリーDOI: 10.2210/pdb3hng/pdb
• 分子名称: Vascular endothelial growth factor receptor 1, N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: receptor tyrosine kinase, vegfr1, flt1, kinase domain, inhibitor, activation loop, vascular endothelial growth factor receptor, structural genomics, structural genomics consortium, sgc, sgc stockholm, angiogenesis, atp-binding, cell membrane, developmental protein, differentiation, disulfide bond, glycoprotein, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform Flt1: Cell membrane; Single-pass type I membrane protein. Isoform sFlt1: Secreted: P17948
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41454.38

構造登録者

Tresaugues, L.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nyman, T.,Persson, C.,Kragh-Nielsen, T.,Kotzch, A.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Van der Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P.,Structural Genomics Consortium (SGC) (登録日: 2009-05-31, 公開日: 2009-06-30, 最終更新日: 2023-11-01)

• 主引用文献: Tresaugues, L.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nyman, T.,Persson, C.,Kragh-Nielsen, T.,Kotzch, A.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Van der Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P.; Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide; To be Published,

実験手法

X-RAY DIFFRACTION (2.7 Å)