3HNA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and mono-Methylated H3K9 Peptide

3HNA の概要

• エントリーDOI: 10.2210/pdb3hna/pdb
• 分子名称: Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, Mono-Methylated H3K9 Peptide, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• 機能のキーワード: ehmt1, structural genomics, sgc, structural genomics consortium, ank repeat, chromatin regulator, metal-binding, methyltransferase, nucleus, phosphoprotein, s-adenosyl-l-methionine, transferase, hydrolase-hydrolase regulator complex, hydrolase/hydrolase regulator
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q9H9B1
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69769.69

構造登録者

Min, J.,Wu, H.,Loppnau, P.,Wleigelt, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Plotnikov, A.N.,Structural Genomics Consortium (SGC) (登録日: 2009-05-30, 公開日: 2009-06-09, 最終更新日: 2023-09-06)

• 主引用文献: Wu, H.,Min, J.,Lunin, V.V.,Antoshenko, T.,Dombrovski, L.,Zeng, H.,Allali-Hassani, A.,Campagna-Slater, V.,Vedadi, M.,Arrowsmith, C.H.,Plotnikov, A.N.,Schapira, M.; Structural biology of human H3K9 methyltransferases; Plos One, 5:e8570-e8570, 2010; PubMed: 20084102; DOI: 10.1371/journal.pone.0008570

実験手法

X-RAY DIFFRACTION (1.5 Å)